In professional and non-professional sports activities, physical exercise can lead to Delayed Onset Muscle Soreness or DOMS.
The level of pain experienced ranges from slight muscle discomfort to a maximum muscle ache enough to limit performance. The onset occurs after around 8–24 hours, with a maximum peak at around 48–96 hours after the exercise. Normal comfort is restored roughly after the 7 to the 10th day.
The biological mechanisms that trigger DOMS are known and basically consist of:
1) muscle sarcomere lesions with the release of pro-inflammatory mediators by the tissues;
2) the activation of specific immune cells (Mastocytes or mast cells), responsible for triggering pain mechanisms and inflammatory edema (by releasing NGF and histamine) and the tissue repair processes (by the release of growth factors).
In such cases the inflammatory process is essential in order to activate the muscle repair processes, and this is why it must not be inhibited with specific medicines to reduce the inflammation.
In cases such as these active ingredients can be employed topically that are able to exert their action by purely natural mechanisms; these molecules include Adelmidrol (an ALIAmide), a substance that encourages the natural neuro-muscular recovery processes while at the same time reducing the pain and the inflammatory edema.