Sweating is a complex biological phenomenon, extraordinarily important for keeping body temperature within physiological limits, is finely controlled at peripheral and central level. The activity of the sweat glands – eccrine and apocrine – is coordinated by the district neuro-endocrine system, which is in turn regulated by the mast cell, a dermal-epidermal tissue-resident cell, with […]
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Distal Diabetic neuropathy is a common complication of diabetes, often chronic and disabling but frequently underestimated and inadequately treated. This short article discusses this emerging problem (affecting 1 in 3 people suffering with diabetes), providing indications on the diagnostic approach and on the latest generation of topical molecules that can be used to restore the […]
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It’s not only Santa Claus’s feet that feel the effects … The Christmas period is a very busy time for many people. In the sales sector, on industrial production lines, in bars and restaurants or in hairdressing salons, but also in hospitals or doctors’ surgeries, over half the employees spend many hours on their feet […]
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In professional and non-professional sports activities, physical exercise can lead to Delayed Onset Muscle Soreness or DOMS. The level of pain experienced ranges from slight muscle discomfort to a maximum muscle ache enough to limit performance. The onset occurs after around 8–24 hours, with a maximum peak at around 48–96 hours after the exercise. Normal […]
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When we talk about hyperalgesic states of the foot we refer to a pain frequently localized in specific foot (metatarsal bones, foot sole and foot neck, etc.) or ankle structures. There are several trigger factors for the hyperalgesic states in the foot: dysmetabolic disorders (e.g. diabetes); foot nerves diseases (e.g. due to drugs, autoimmune conditions, […]
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Among the diabetes complications, we found the diabetic foot, a severe disabling chronic condition, sustained by blood vessels damage (driven by oxidative stress) and by nerves injury (diabetic neuropathy ) affecting lower limbs. The sensory deficit typical in case of diabetic foot (not feeling pain or perceiving tactile stimuli) is frequently associated with a skin […]
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