
Living with foot peripheral neuropathy means having to deal with symptoms such as pain, tingling, motor limitations and reduced sensitivity to thermal stimuli or pressure.
The chronic-progressive nature of the pathology and the absence of specific therapies make it essential to identify and early manage the underlying cause of nerve suffering. Controlling sensory symptoms is also helpful in regulating terminal nerve function and improving the psychophysical state of people with peripheral neuropathy.
The disease is particularly common among diabetics: in fact, about half of them develop neuropathy over the years, which manifests itself with a neuropathic pain in 15-25% of cases[1] , and can worsen contributing to the onset of “diabetic foot,” a more complex condition associated with the risk of deep tissue injury, local and systemic infections. The pathogenesis can also be attributed to infectious or inflammatory causes, local trauma, or pharmacological therapies such as anti-cancer drugs.
The altered biological mechanisms underlying foot neuropathy
From a biological point of view, peripheral neuropathy is the manifestation of a cellular hyper-reactivity state in foot dermo-epidermal tissues, regardless of the triggering factors. In addition to small nerve fibres, specific cells of the immune system, mast cells, are involved in this altered mechanism. In particular, mast cells are responsible for the release of pro-inflammatory substances triggering pathological symptoms.
Therefore, a protective approach, aimed to contain the nerve damage, involves restoring the altered neuro-immune balance.
CAPSIPOD® COMPLEX goes in this direction, combining the neuroprotective and antioxidant effect with the modulatory action of Adelmidrol, an exclusive component of podolife® products for topical use.
CAPSIPOD® COMPLEX, topical action for regulating the neuro-epidermal function
The specific formulation of CAPSIPOD® COMPLEX contains a low dosage of Capsaicin, which attenuates pain transmission. In addition, menthol relieves tingling or itching sensation, thanks to its cooling effect on the skin.
Rutin also promotes the capillaries tone and elasticity, improving circulation: in fact, peripheral nerve damage is also related to altered blood flow due, for example, to diabetes.
Finally, Adelmidrol regulates the activity of mast cells located in the foot skin, promoting the physiological nerve function, and thus normalizing the pain threshold.